Introduction: Depression can have unfavorable complications for the mother and the baby. Given the probable relationship of social support with the amount of depression, the present study aimed to determine the relationship between perceived social support and depression, before and after cesarean in the pregnant women referring to Besat Hospital in Sanandaj in 2018.\nMaterials and methods: The present study is descriptive co-relational and cross-sectional, and was conducted on 180 pregnant women enrolled for the cesarean section referring to Besat hospital in 2018 who were selected according to available sampling method. The demographic information questionnaire, the perceived social support of MOS-SSS, and the depression, questionnaires Dass 21 were used to collect data. Using the SPSS 16 software, the data was analyzed through descriptive statistics, Pearson co-relation.\nResults : Results indicated that the degree of the overall rate of depression, before cesarean was 35.5% and in the post operation stage 21.7% respectively. In addition, there was a negative significant difference between social support and depression, before the operation (p<0.05, r= -0.816), and depression, after cesarean (P<0.05, r= -0.788).\nConclusion: The results of the study showed that there is a negative and significant relationship between perceived social support and depression, before and after cesarean section. Hence it is advised that interventions be designed to identify and promote the level of social support in the pregnant women enrolled for Cesarean.